When Brief Therapy Worked and Medication Did Not

Molecularly targeted therapy for Kaposi's sarcoma in a kidney transplant patient: case report, "what worked and what did not"

BACKGROUND Imatinib is a tyrosine-kinase inhibitor; for which there is limited information regarding its effects on AIDS Kaposi's sarcoma and none in patients with transplant-associated Kaposi's sarcoma. Sirolimus, an immunosuppressive drug used for kidney transplant, exhibits antiangiogenic activity related to impaired production of VEGF (vascular endothelial growth factor), clinical benefit h...

Data Mining with MineSet: What Worked, What Did Not, and What Might

At Silicon Graphics, Inc., we have developed a data mining and visualization product called MineSet(Silicon Graphics 1998, Brunk, Kelly & Kohavi 1997). MineSet first released in early 1996 mostly as a visualization product and then became a full data mining and visualization product late that year with several data mining algorithms based onMLC++ (Kohavi, Sommerfield & Dougherty 1997). The engi...

Pregnant, even when you did not want to be pregnant.

What did they know, and when did they know it?

voted to ease monetary policy, which was widely reported as a lowering of interest rates. Although some interest rates fell with the Fed' s action, the declines were generally small, and over succeeding months market interest rates tended to rise. The yield on the Treasury' s 10-year note, for example, which had been 5.63 percent on January 30, and which closed at 5.60 percent on January 31, st...

When medication is not enough: nonpharmacologic management of pain.

Patients with cancer commonly experience pain, which typically is controlled pharmacologically. Despite advances in pain management, pain continues to be undertreated. Nonpharmacologic measures may effectively manage pain but often are overlooked or underused. Nurses who are familiar with simple, noninvasive, nonpharmacologic measures, such as patient positioning, thermal measures, massage ther...